Jesy Nelson is taking an 'extended break' from Little Mix.
The official announcement comes after the singer has missed several appearances with the band in recent weeks, including the final of their BBC One talent show The Search and their hosting gig at the MTV Europe Music Awards.
After growing concern from fans, a spokesperson for the group confirmed her temporary departure in a statement.
They shared: "Jesy is having extended time off from Little Mix for private medical reasons.
"We will not be issuing any further comment currently and ask media to please respect her privacy at this time."
It is not yet known when Jesy will be back with the chart-topping group.
Fans had been sharing their worries for Jesy after she became a noticeable absence at more than one of Little Mix's high profile appearances in the last month.
It was first revealed that she would not be joining bandmates Jade Thirlwall, Leigh-Anne Pinnock and Perrie Edwards for the final of their talent show The Search earlier this month.
At the time a representative of the band said that Jesy was too 'unwell' to appear in the studio.
They told viewers: "Jesy is unwell and will not be appearing on tonight’s final of Little Mix: The Search.
“She will also not be hosting or performing at tomorrow’s MTV EMAs,” they also revealed.
Perrie, Leigh-Anne and Jade were forced to present the virtual ceremony without her.
Fans then became suspicious when Jesy's signature was left off signed copies of Little Mix's new album Confetti.
It came after the singer was accused of looking "over it" in a now-deleted Little Mix video promoting their sixth studio album.
While Leigh-Anne, Jade and Perrie were full of beans speaking about Confetti, Jesy was seen rolling her eyes and looking downbeat.
The members of Little Mix became household names in 2011 when they were put together on The X Factor, before going on to make history as the first group to win the show.
Since then the ever popular foursome have gone on to become one of the biggest selling girlband's in UK history.
While their 2020 tour had to be cancelled due to the coronavirus pandemic, Little Mix have continued to work tirelessly over the last 11 months with the release of their sixth studio album Confetti along with four singles and accompanying music vidoes.
As well as recording new material, the band also began filming their own reality TV music series The Search, which began airing on BBC One in September.
Jesy joined Jade, Perrie and Leigh-Anne for the live shows but did not appear for the final, where band September were crowned the overall winners.
The star, who usually? boasts an active social media presence, has not posted to Instagram since she got dressed up in costume for Halloween in October.
A few weeks before Jesy took to the site to confirm her relationship with Our Girl actor Sean Sagar.
The pair had been rumoured to be dating after fans noticed them exchanging a series of flirty exchanges back and forth before they finally made things official.
Jesy shared a picture of Sean giving her a kiss on the cheek as she called him her 'Everything' in the caption.
Sean then shared a similar photo to his social media page, where he described the pop star as: "The reason for my happiness ?"